The Role of Genetic Variations and Molecular Signature in Active and Inactive Systemic Lupus Erythematosus

In a new study, researchers looked to understand the changes in the molecular structure of systemic lupus erythematosus (SLE), looking specifically at disease remission and discovered several genetic features during remission compared to active disease. 

A group of people with inactive SLE (26), active SLE (76) and healthy people (15) were studied. They analyzed their genetic variations and immune pathways, as well as the construction of protein-protein interaction networks. Several genetic variations were recovered in individuals during remission compared to those in active disease. Recovered features included reduction of plasma and cell cycle signatures and increase of lymphocytes, a type of white blood cell that play an essential role in the immune system. 

The discovery of genetic features and molecular signatures in remission may potentially help to develop biomarkers for tracking disease activity, drug therapies to prevent disease relapse, as well as targeted strategies for treatment. Learn more about understanding lupus.

Read the study