Connect with us

Fitness

Polypharmacy and drug interactions in older patients with cancer receiving chemotherapy: associated factors – BMC Geriatrics

Published

on

Polypharmacy and drug interactions in older patients with cancer receiving chemotherapy: associated factors – BMC Geriatrics

  • Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144(8):1941–53.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Berben L, Floris G, Wildiers H, Hatse S. Cancer and aging: two tightly interconnected biological processes. Cancers. 2021;13(6):1400.

  • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.

    Article 
    PubMed 

    Google Scholar
     

  • Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA Cancer J Clin. 2021;71(1):7–33.

    Article 
    PubMed 

    Google Scholar
     

  • Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49.

  • Mannucci PM, Nobili A. Multimorbidity and polypharmacy in the elderly: lessons from REPOSI. Intern Emerg Med. 2014;9(7):723–34.

    Article 
    PubMed 

    Google Scholar
     

  • Caillet P, Laurent M, Bastuji-Garin S, Liuu E, Culine S, Lagrange JL, et al. Optimal management of elderly cancer patients: usefulness of the comprehensive geriatric assessment. Clin Interv Aging. 2014;9:1645–60.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Caillet P, Canoui-Poitrine F, Vouriot J, Berle M, Reinald N, Krypciak S, et al. Comprehensive geriatric assessment in the decision-making process in elderly patients with cancer: ELCAPA study. J Clin Oncol. 2011;29(27):3636–42.

    Article 
    PubMed 

    Google Scholar
     

  • Balducci L, Goetz-Parten D, Steinman MA. Polypharmacy and the management of the older cancer patient. Ann Oncol. 2013;24 Suppl 7(Suppl 7):vii36-40.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jorgensen TL, Herrstedt J, Friis S, Hallas J. Polypharmacy and drug use in elderly Danish cancer patients during 1996 to 2006. Journal of geriatric oncology. 2012;3(1):33–40.

    Article 

    Google Scholar
     

  • Park HY, Ryu HN, Shim MK, Sohn HS, Kwon JW. Prescribed drugs and polypharmacy in healthcare service users in South Korea: an analysis based on National Health Insurance Claims data. Int J Clin Pharmacol Ther. 2016;54(5):369–77.

    Article 
    PubMed 

    Google Scholar
     

  • Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 2017;17(1):230.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hong S, Lee JH, Chun EK, Kim KI, Kim JW, Kim SH, et al. Polypharmacy, Inappropriate medication use, and drug interactions in older korean patients with cancer receiving first-line palliative chemotherapy. Oncologist. 2020;25(3):e502–11.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nightingale G, Pizzi LT, Barlow A, Barlow B, Jacisin T, McGuire M, et al. The prevalence of major drug-drug interactions in older adults with cancer and the role of clinical decision support software. J Geriatric Oncol. 2018;9(5):526–33.

    Article 
    PubMed 

    Google Scholar
     

  • Jørgensen TL, Herrstedt J. The influence of polypharmacy, potentially inappropriate medications, and drug interactions on treatment completion and prognosis in older patients with ovarian cancer. J Geriatric Oncol. 2020;11(4):593–602.

    Article 
    PubMed 

    Google Scholar
     

  • Lavan AH, O’Mahony D, O’Mahony D, Gallagher P. Potentially inappropriate medication (PIM) use and severe drug interactions (SDIs) in older adults with cancer. J Geriatric Oncol. 2021;12(6):872-80.

  • Midão L, Giardini A, Menditto E, Kardas P, Costa E. Polypharmacy prevalence among older adults based on the survey of health, ageing and retirement in Europe. Arch Gerontol Geriatr. 2018;78:213–20.

    Article 
    PubMed 

    Google Scholar
     

  • Candeias C, Gama J, Rodrigues M, Falcão A, Alves G. Patients’ Characterization, Pattern of Medication Use, and Factors Associated with Polypharmacy: A Cross-Sectional Study Focused on Eight Units of the Portuguese National Network for Long-Term Integrated Care. Healthcare (Basel). 2023;12(1):57.

  • Whitman AM, DeGregory KA, Morris AL, Ramsdale EE. A Comprehensive look at polypharmacy and medication screening tools for the older cancer patient. Oncologist. 2016;21(6):723–30.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Turner JP, Shakib S, Singhal N, Hogan-Doran J, Prowse R, Johns S, Bell JS. Prevalence and factors associated with polypharmacy in older people with cancer. Support Care Cancer. 2014;22(7):1727–34.

    Article 
    PubMed 

    Google Scholar
     

  • Turner JP, Jamsen KM, Shakib S, Singhal N, Prowse R, Bell JS. Polypharmacy cut-points in older people with cancer: how many medications are too many? Support Care Cancer. 2016;24(4):1831–40.

    Article 
    PubMed 

    Google Scholar
     

  • Ussai S, Petelin R, Giordano A, Malinconico M, Cirillo D, Pentimalli F. A pilot study on the impact of known drug-drug interactions in cancer patients. J Exp Clin Cancer Res. 2015;34(1):89.

    Article 
    PubMed Central 

    Google Scholar
     

  • Beijnen JH, Schellens JH. Drug interactions in oncology. Lancet Oncol. 2004;5(8):489–96.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Scripture CD, Figg WD. Drug interactions in cancer therapy. Nat Rev Cancer. 2006;6(7):546–58.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Blower P, de Wit R, Goodin S, Aapro M. Drug-drug interactions in oncology: why are they important and can they be minimized? Crit Rev Oncol Hematol. 2005;55(2):117–42.

    Article 
    PubMed 

    Google Scholar
     

  • Alkan A, Yasar A, Karci E, Koksoy EB, Urun M, Senler FC, et al. Severe drug interactions and potentially inappropriate medication usage in elderly cancer patients. Support Care Cancer. 2017;25(1):229–36.

    Article 
    PubMed 

    Google Scholar
     

  • Mohamed MR, Ramsdale E, Loh KP, Arastu A, Xu H, Obrecht S, et al. Associations of Polypharmacy and Inappropriate Medications with Adverse Outcomes in Older Adults with Cancer: A Systematic Review and Meta-Analysis. Oncologist. 2020;25(1):e94–108.

    Article 
    PubMed 

    Google Scholar
     

  • Lavan AH, O’Mahony D, Buckley M, O’Mahony D, Gallagher P. Adverse Drug Reactions in an Oncological Population: Prevalence, Predictability, and Preventability. Oncologist. 2019;24(9):e968–77.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Maggiore RJ, Dale W, Gross CP, Feng T, Tew WP, Mohile SG, et al. Polypharmacy and potentially inappropriate medication use in older adults with cancer undergoing chemotherapy: effect on chemotherapy-related toxicity and hospitalization during treatment. J Am Geriatr Soc. 2014;62(8):1505–12.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Park JW, Roh JL, Lee SW, Kim SB, Choi SH, Nam SY, Kim SY. Effect of polypharmacy and potentially inappropriate medications on treatment and posttreatment courses in elderly patients with head and neck cancer. J Cancer Res Clin Oncol. 2016;142(5):1031–40.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Dhalwani NN, Fahami R, Sathanapally H, Seidu S, Davies MJ, Khunti K. Association between polypharmacy and falls in older adults: a longitudinal study from England. BMJ Open. 2017;7(10):e016358.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Saum KU, Schöttker B, Meid AD, Holleczek B, Haefeli WE, Hauer K, Brenner H. Is polypharmacy associated with frailty in older people? results from the esther cohort study. J Am Geriatr Soc. 2017;65(2):e27–32.

    Article 
    PubMed 

    Google Scholar
     

  • Schöttker B, Saum KU, Muhlack DC, Hoppe LK, Holleczek B, Brenner H. Polypharmacy and mortality: new insights from a large cohort of older adults by detection of effect modification by multi-morbidity and comprehensive correction of confounding by indication. Eur J Clin Pharmacol. 2017;73(8):1041–8.

    Article 
    PubMed 

    Google Scholar
     

  • Sharma M, Loh KP, Nightingale G, Mohile SG, Holmes HM. Polypharmacy and potentially inappropriate medication use in geriatric oncology. J Geriatr Oncol. 2016;7(5):346–53.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Popa MA, Wallace KJ, Brunello A, Extermann M, Balducci L. Potential drug interactions and chemotoxicity in older patients with cancer receiving chemotherapy. J Geriatr Oncol. 2014;5(3):307–14.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Beinse G, Reitter D, Segaux L, Carvahlo-Verlinde M, Rousseau B, Tournigand C, et al. Potential drug-drug interactions and risk of unplanned hospitalization in older patients with cancer: A survey of the prospective ELCAPA (ELderly CAncer PAtients) cohort. J Geriatr Oncol. 2020;11(4):586–92.

    Article 
    PubMed 

    Google Scholar
     

  • Nightingale G, Hajjar E, Swartz K, Andrel-Sendecki J, Chapman A. Evaluation of a pharmacist-led medication assessment used to identify prevalence of and associations with polypharmacy and potentially inappropriate medication use among ambulatory senior adults with cancer. J Clin Oncol. 2015;33(13):1453–9.

    Article 
    PubMed 

    Google Scholar
     

  • Lees J, Chan A. Polypharmacy in elderly patients with cancer: clinical implications and management. Lancet Oncol. 2011;12(13):1249–57.

    Article 
    PubMed 

    Google Scholar
     

  • Budnitz DS, Lovegrove MC, Shehab N, Richards CL. Emergency hospitalizations for adverse drug events in older Americans. N Engl J Med. 2011;365(21):2002–12.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Marcum ZA, Amuan ME, Hanlon JT, Aspinall SL, Handler SM, Ruby CM, Pugh MJ. Prevalence of unplanned hospitalizations caused by adverse drug reactions in older veterans. J Am Geriatr Soc. 2012;60(1):34–41.

    Article 
    PubMed 

    Google Scholar
     

  • Prithviraj GK, Koroukian S, Margevicius S, Berger NA, Bagai R, Owusu C. Patient characteristics associated with polypharmacy and inappropriate prescribing of medications among older adults with cancer. J Geriatr Oncol. 2012;3(3):228–37.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Maggiore RJ, Gross CP, Hurria A. Polypharmacy in older adults with cancer. Oncologist. 2010;15(5):507–22.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Drug Interaction Checking (electronic version). IBM Watson Health. [Internet]. [cited January, 2021]. Available from: https://www.micromedexsolutions.com.

  • Bossaer JB, Thomas CM. Drug Interaction Database Sensitivity With Oral Antineoplastics: An Exploratory Analysis. Journal of oncology practice. 2017;13(3):e217–22.

    Article 
    PubMed 

    Google Scholar
     

  • KY-L Yap, S Raaj, A Chan. OncoRx-IQ: a tool for quality assessment of online anticancer drug interactions. Int J Qual Health Care. 2010;22(2):93–106.

    Article 

    Google Scholar
     

  • Mitry MA, Edwards JG. Doxorubicin induced heart failure: Phenotype and molecular mechanisms.Int J Cardiol Heart Vasculature. 2016;10:17–24.

    Article 

    Google Scholar
     

  • Anfinson TJ. Akathisia, panic, agoraphobia, and major depression following brief exposure to metoclopramide. Psychopharmacol Bull. 2002;36(1):82–93.

    PubMed 

    Google Scholar
     

  • Dean L, Kane M. Tramadol Therapy and CYP2D6 Genotype. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kane MS, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

  • Li Y, Ding D, Jiang H, Fu Y, Salvi R. Co-administration of cisplatin and furosemide causes rapid and massive loss of cochlear hair cells in mice. Neurotox Res. 2011;20(4):307–19.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Crona DJ, Faso A, Nishijima TF, McGraw KA, Galsky MD, Milowsky MI. A systematic review of strategies to prevent cisplatin-induced nephrotoxicity. Oncologist. 2017;22(5):609–19.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pfizer. DOXORUBICIN Drug Interactions. Prescribing Information. Available: https://www.pfizermedicalinformation.com/en-us/doxorubicin/drug-interactions.

  • Schenk M, Wirz S. Serotonin syndrome and pain medication : What is relevant for practice? Schmerz (Berlin, Germany). 2015;29(2):229–51.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Weintraub M, Adde MA, Venzon DJ, Shad AT, Horak ID, Neely JE, et al. Severe atypical neuropathy associated with administration of hematopoietic colony-stimulating factors and vincristine. J Clin Oncol. 1996;14(3):935–40.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Khan Q, Ismail M, Khan S. Frequency, characteristics and risk factors of QT interval prolonging drugs and drug-drug interactions in cancer patients: a multicenter study. BMC Pharmacol Toxicol. 2017;18(1):75.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guven DC, Kavgaci G, Aktepe OH, Yildirim HC, Sahin TK, Aksoy S, et al. The burden of polypharmacy and drug-drug interactions in older cancer patients treated with immunotherapy. J Oncol Pharm Pract. 2022;28(4):785-93.

  • Paul T, Palatty PL, Adnan M, George T, Rao S, Baliga MS. Audit of drug-drug interactions and adverse drug reactions due to polypharmacy in older cancer patients: First report from India. Indian J Cancer. 2020;57(4):405–10.

    Article 
    PubMed 

    Google Scholar
     

  • Scheife RT, Hines LE, Boyce RD, Chung SP, Momper JD, Sommer CD, et al. Consensus recommendations for systematic evaluation of drug-drug interaction evidence for clinical decision support. Drug Saf. 2015;38(2):197–206.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Roblek T, Vaupotic T, Mrhar A, Lainscak M. Drug-drug interaction software in clinical practice: a systematic review. Eur J Clin Pharmacol. 2015;71(2):131–42.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kheshti R, Aalipour M, Namazi S. A comparison of five common drug-drug interaction software programs regarding accuracy and comprehensiveness. J Res Pharm Pract. 2016;5(4):257–63.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • van Leeuwen RWF, Jansman FGA, van den Bemt P, de Man F, Piran F, Vincenten I, et al. Drug-drug interactions in patients treated for cancer: a prospective study on clinical interventions. Ann Oncol
    . 2015;26(5):992–7.

    Article 
    PubMed 

    Google Scholar
     

  • Klotz U. Pharmacokinetics and drug metabolism in the elderly. Drug Metab Rev. 2009;41(2):67–76.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Shi S, Klotz U. Age-related changes in pharmacokinetics. Curr Drug Metab. 2011;12(7):601–10.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Adem L, Tegegne GT. Medication appropriateness, polypharmacy, and drug-drug interactions in ambulatory elderly patients with cardiovascular diseases at tikur anbessa specialized hospital. Ethiopia Clin Interv Aging. 2022;17:509–17.

    Article 
    PubMed 

    Google Scholar
     

  • Sheikh-Taha M, Asmar M. Polypharmacy and severe potential drug-drug interactions among older adults with cardiovascular disease in the United States. BMC Geriatr. 2021;21(1):233.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Al-Musawe L, Torre C, Guerreiro JP, Rodrigues AT, Raposo JF, Mota-Filipe H, Martins AP. Polypharmacy, potentially serious clinically relevant drug-drug interactions, and inappropriate medicines in elderly people with type 2 diabetes and their impact on quality of life. Pharmacol Res Perspect. 2020;8(4):e00621.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Alwhaibi M, Balkhi B, Alhawassi TM, Alkofide H, Alduhaim N, Alabdulali R, et al. Polypharmacy among patients with diabetes: a cross-sectional retrospective study in a tertiary hospital in Saudi Arabia. BMJ Open. 2018;8(5):e020852.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Woopen H, Richter R, Ismaeel F, Chekerov R, Roots I, Siepmann T, Sehouli J. The influence of polypharmacy on grade III/IV toxicity, prior discontinuation of chemotherapy and overall survival in ovarian cancer. Gynecol Oncol. 2016;140(3):554–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Whitman A, DeGregory K, Morris A, Mohile S, Ramsdale E. Pharmacist-led medication assessment and deprescribing intervention for older adults with cancer and polypharmacy: a pilot study. Support Care Cancer. 2018;26(12):4105–13.

    Article 
    PubMed 

    Google Scholar
     

  • Nipp RD, Ruddy M, Fuh CX, Zangardi ML, Chio C, Kim EB, et al. Pilot Randomized Trial of a Pharmacy Intervention for Older Adults with Cancer. Oncologist. 2019;24(2):211–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nightingale G, Hajjar E, Pizzi LT, Wang M, Pigott E, Doherty S, et al. Implementing a pharmacist-led, individualized medication assessment and planning (iMAP) intervention to reduce medication related problems among older adults with cancer. J Geriatr Oncol. 2017;8(4):296–302.

    Article 
    PubMed 

    Google Scholar
     

  • Lopez-Martin C, Garrido Siles M, Alcaide-Garcia J, Faus FV. Role of clinical pharmacists to prevent drug interactions in cancer outpatients: a single-centre experience. Int J Clin Pharm. 2014;36(6):1251–9.

    Article 
    PubMed 

    Google Scholar
     

  • Girre V, Arkoub H, Puts MT, Vantelon C, Blanchard F, Droz JP, Mignot L. Potential drug interactions in elderly cancer patients. Crit Rev Oncol Hematol. 2011;78(3):220–6.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Continue Reading