Can we change how our brains age? Scientists think it’s possible – BBC News

Computer models that assess how our brains age and predict their decline were shown to me by Andrei Irimia, associate professor of gerontology and computational biology at the University of Southern California.

He had created them using MRI scans, data from 15,000 brains and the power of artificial intelligence to understand the trajectory of both brains that are ageing healthily and those in which there is a disease process, such as dementia.

“It’s a very sophisticated way to look at patterns that we don’t necessarily know about as humans, but the AI algorithm is able to pick up on them,” he said.

Prof Irimia did, of course, take a look inside my head.

I’d had a functional MRI scan ahead of my visit and, after analysing its results, Prof Irimia told me I had a brain age eight months older than my chronological age (although apparently the bit that controls talking wasn’t ageing so much. I could have told him that). However, Prof Irimia suggested that the results fall within a two-year error margin.

Private companies are starting to commercialise this technology, too. One firm, Brainkey, is offering the service in a variety of clinics around the world. Its founder Owen Philips told me that in future, getting an MRI should become easier.

“It’s becoming much more accessible for people to get an MRI scan, and the images coming off them are getting even better and better,” he said.

“I don’t mean to nerd out there. But the technology is just getting to a point where we are able to see things much earlier than we could in the past. And that means we can understand exactly what’s happening in an individual patient’s brain. With AI, we can support that.”

In contrast to what Prof Irimia’s analysis of my MRI scan had told me, Brainkey’s estimate knocked a year off my brain’s biological age. I was also presented with a 3D-printed model of it, which appeared substantial and, I was assured, was life-sized.

The aim here is not just a more precise approach to treatment, but also to be able to quantify how well any interventions are working.

Dramatic increases in life expectancy over the past 200 years have given rise to a host of age-related diseases. I did wonder whether, if we all lived long enough, dementia might come knocking at all our doors.

Prof Irimia said this was a theory many have investigated albeit not proven, adding that the aim was to find a way to keep on pushing dementia back, hopefully beyond our life expectancies.

And all of this takes us back to the same point. Every scientist and doctor, as well as those Blue Zoners, say lifestyle is key. Good diet, keeping active, mentally stimulated and happy are crucial to how our brains age.

There’s another important factor too, according to Matthew Walker, professor of neuroscience and psychology at the University of California, Berkeley, and author of the best-selling book Why We Sleep.

“Sleep is the single most effective thing you can do every day to reset your brain and body health,” he evangelised. “There is no operation of your mind that is not wonderfully enhanced when you get sleep, or demonstrably impaired when you don’t get enough.”

He spoke of our brains’ cleansing system, which functions during our slumber by washing away the beta-amyloid and tau proteins – these are “two of the main culprits underlying Alzheimer’s”.

Changes in sleep patterns are also associated with dementia. Prof Walker described how we don’t just see this in our 60s or 70s – it can begin during our 30s. So, identifying those changes through sleep tracking could potentially become a “model of midlife prevention”.