£8m Longitude prize won for tackling superbug rise – BBC News

The £8m Longitude Prize has been won after a decade-long competition to find new tools to tackle the scourge of superbugs.

It has been awarded for a test that rapidly detects whether an infection is caused by bacteria and identifies the right antibiotics to treat it.

The test takes 45 minutes, compared with three days using traditional methods.

The original work was done by Swedish researchers and the test is now being sold by the company Sysmex Astrego.

The Longitude Prize – with a financial reward nearly 10 times that of a Nobel – was inspired by a contest in 1714.

It was won by John Harrison, who developed a precise clock allowing sailors to pinpoint their position at sea – one of the greatest challenges of the 18th Century.

Fast forward 300 years – and the modern blight of superbugs was the focus.

Infections that resist the drugs used to treat them are estimated to kill more than a million people every year. It is known as the silent pandemic.

“Without antibiotics, modern medicine as we know it is in real danger of collapse,” UK special envoy on antimicrobial resistance Dame Sally Davies says.

Every time an antibiotic is used creates an opportunity for bacteria in the body to evolve resistance to it.

Resistance gives those bacteria a survival advantage and they spread, which is why the life-saving drugs should be used only when it is certain they will work.

The test works in urinary tract infections, which affect most women at some point and account for a fifth of antibiotics prescribed in England.

When the patient first arrives in hospital, or at a doctor’s surgery, it is not easy to tell if their infection is caused by bacteria, viruses or even fungi.

Doctors can send a sample to a clinical microbiology laboratory – but this means growing the bacteria on a petri dish and can take three days to reveal the cause and which antibiotics the infection may be susceptible to.

In the meantime, antibiotic treatment is often started anyway because of the risk of symptoms becoming much worse or even causing sepsis.

The prize-winning test, however, reveals within 15 minutes whether the infection is bacterial – and within 45 minutes, which antibiotics work.

It starts with a urine sample, which is squirted into a cartridge containing tiny doses of five different antibiotics and placed inside a machine.

Any bacteria are forced – in single file – into one of thousands of channels inside the cartridge.

The machine then uses microscopy to monitor how any bacteria grow in the presence of the different drugs.

And the antibiotics that lead to little or no growth are the most likely to work.